Fig. 4

OP is a reservoir of antibiotic resistance genes with the potential for horizontal transfer. A Species annotation of ARG-carrying contigs (ACCs). Species contributing more than 30 ACCs of at least a type of ARG are shown. B Distribution of the ARGs within ACCs in opportunistic pathogens colonizing the upper respiratory tract. Species abundance distribution is shown on the right side of the figure. C Correlation between the proportion of mobile ACCs and the number of host species for different ARGs. ARGs detected in at least 100 ACCs are shown. D Illustrations of two ACCs that are associated with the highest numbers of microbial hosts. The upper part displays the structures of two ACCs, while the lower part displays the number of participants with these two ACCs in each species host. E Sequence similarity of the aac(6')-aph(2'') gene and its downstream 500 bp between different species in contigs with MGEs (upper) and without MGEs (lower). Gray lines represent the similarity between sequences in two different species (with 50 bp sliding windows used), the blue line indicates the mean of all gray lines, and the shadow represents the 95% confidence interval