Fig. 4
The oral microbiota of halitosis patients with different genotypes during the 6-month follow-up. A Shannon index of individuals with different genotypes. Data are presented as mean ± SD. **, P < 0.01. B-C β diversity comparison between baseline and 6-month after treatment in the non-AVI/AVI group (B) and AVI/AVI group (C), respectively. Statistical analysis of β diversity was performed using adonis. The bar plots illustrate the PCoA1 and PCoA2 dimensions of β diversity, respectively. D-E Volcano plot (D) and heat map (E) of genera with deferential expression pattern in AVI/AVI genotype compared with non-AVI/AVI genotype at 6th-month post-treatment (Padj< 0.05 by Benjamini–Hochberg FDR method). F LEfSe analysis and LDA scores for representative microbiota in AVI/AVI genotype and non-AVI/AVI genotype at 6th-month post-treatment