Fig. 3

Differences in contributional functional diversity and enriched functional pathways between clusters 1 and 2. a Differences in contributional diversity between clusters for core MetaCyc pathways (pathways present in ≥ 75% of samples within each cluster). Core pathways detected in both clusters are labeled as “shared” (triangles). b Examples of conserved pathways (biosynthesis of homocysteine, cysteine, and L-methionine) illustrating differences in contributional diversity between clusters. c Enrichment of MetaCyc pathways between clusters analyzed using MaAslin2. Only the top 50 statistically significant pathways (adjusted p < 0.05) are shown