Skip to main content
Fig. 1 | Microbiome

Fig. 1

From: Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection

Fig. 1

F.prausnitzii alleviates intestinal viral infection in a piglet model. a Development of a functional model for F.prausnitzii; piglet small intestines were sampled on day 5 post-infection to assess intestinal damage, Fp + PEDV (n = 8), PEDV (n = 8), Control (n = 5). Comparative analysis of clinical indicators of survival (b), weight loss (c), and diarrhea (d) among the piglet groups. e Analysis of epithelial cell shedding from pathological sections. f Comparison of histopathological changes (H&E staining); images taken at 20 × and 100 × magnifications. g Alterations in intestinal appearance. h Scanning electron microscopy (SEM) examination of jejunal villi; images taken at 10 × , 200 × , and 500 × magnifications. i Assessment of relative PEDV-S expression levels in the intestines. j Immunofluorescence analysis of the intestines using PEDV-S; images taken at 100 × magnification. k Characterization of viral content in intestinal epithelial cells using PEDV-N. Results are shown as means ± SD, with statistical significance determined by t tests for two groups and one-way ANOVA for three groups. *P < 0.05; **P < 0.01; ****P < 0.0001. Panels a was created with BioRender.com

Back to article page

Microbiome

ISSN: 2049-2618

Contact us