Fig. 3
From: The fungal microbiota modulate neonatal oxygen-induced lung injury
Microbiome-driven clustering analysis of heterogeneity in the mycobiome. A Principal Coordinates Analysis (PCoA) plot showing a five-cluster Dirichlet-Multinomial Mixture (DMM) model clustering of the mycobiome, n = 102. In Cluster 1, 3 infants developed BPD, and 18 did not (NoBPD). In Cluster 2: 6 BPD, 7 NoBPD, Cluster 3: 9 BPD and 3 NoBPD, Cluster 4: 5 BPD and 6 NoBPD, Cluster 5: 1 BPD and 5 NoBPD. B Fungal community diversity analyses indicate the greatest microbial richness in Cluster 3, as quantified by the Shannon diversity index. Values represent means ± SEM. Significance testing by ANOVA. C Average relative abundance of fungi in each DMM cluster. D–F A two-cluster DMM model in NoBPD infants, with the greatest richness in Cluster 2, n = 64. G–I A two-cluster DMM model in BPD infants with the highest microbial richness in Cluster 2, n = 38. Clust1–5, Cluster 1–5. Ellipses indicate the 95% confidence interval. See also Fig. S8–10