Fig. 2

Comparison of different distance metrics using mouse gut microbiome dataset. A Based on taxon-function table without incorporating phylogenetic information (Euclidean, Bray–Curtis, Jaccard) and based on taxon-function table informed by phylogenetic tree (PhyloFunc). B The four distance metrics are based on the sum of functions across Bacteroides species. C The four distance metrics are based solely on the species of Bacteroides. D The four distances metrics based on the species excluding Bacteroides