Fig. 4

Metabolic pathway steps augmented by AMGs. Through enrichment analysis, the abundance of AMGs and their microbial homologs were assessed in virus versus microbial contigs across 146 AMGs with KEGG annotation. Shown here (A–E) are microbial metabolic pathways where at least one step was enriched for viruses, as determined by the abundance of a virus-encoded AMG (red text) being higher than that of their microbial homologs. Virus-enriched AMGs are starred (yellow). References (black) are enzymes involved in reaction steps per pathway as defined in the MetaCyc database. Reaction steps are indicated via circled numbers, and those lacking a number are independent of enzymatic reactions. F Summary data for virus-enriched AMGs and their levels of enrichment (the number on top of each bar) are provided as a bar chart